Abstract: Currently people are engaging developing LTE femtocell to push the commercial use. How to make the LTE femto BS small and low cost is important. It will be the key to successful application in wireless networks. It is a unique chal lenge for the radio transceiver design to minimize cost while maintaining base-station performance. In this paper, a low cost MIMO RF transceiver for LTE femto base station is designed. Based on the transmitter and receiver requirements analysis, block level RF parameters are assigned. Through this approach, the RF transceiver has been systematically divided into sev eral sub-modules; each sub-module is then separately designed and characterized. The obtained measurement results demon strate that the fully integrated RF transceiver design not only has small size but also meets the LTE femto BS requirements.