Abstract: Cell one is fabricated using the magneto-electro-dielectric waveguided metamaterials, MED-WG-MTM via the periodically loaded complementary split-ring resonators(CSRRs) on the upper isosceles right triangle patch and cross-slot on the bottom ground plane, respectively, on the basis of cell one, intercepting a part of bottom ground plane below the patch to fabricate cell two. Analyze the left-handed characteristic and the mechanism of enhancing the gain at higher frequency part. A wideband multi-frequency patch antenna is fabricated by loading cell two, finally. The simulation results show that the patch antenna presents the desired four bandwidths which cover all the 2.4/5.2/5.8 GHz Bluetooth/RFID/WLAN bands and the 2.5/3.5 GHz WiMAX band, including 0.29 GHz(2.33~2.62 GHz), 1.01 GHz(3.11~4.12 GHz), 0.39 GHz(4.97~5.36 GHz), 0.41 GHz(5.74~6.15 GHz). Due to the fact that the effective medium parameters of substrate of antenna are affected by the left-hand characteristic, the wave propagation direction of antenna is changed, which induces the strongest radiation been in horizontal direction rather than the vertical direction of the conventional patch antenna at higher frequency part.