Abstract: The microstrip lines with non-parallel interconnection structure is prevalent in the printed circuit board (PCB). Aiming at the problem of far-end crosstalk between non-parallel microstrip lines, using parallel microstrip lines to approximate non-parallel microstrip lines, the crosstalk cancellation method of parallel coupled microstrip lines is applied to the non-parallel coupled microstrip line, a crosstalk cancellation method of non-parallel microstrip lines based on eigen value decomposition of non-parallel coupled transmission lines-channel transmission matrix is proposed. The crosstalk for non-parallel microstrip lines whose angles are 3°,5°,10° is simulated, results show that crosstalk can be mostly eliminated and the quality of eye diagram can be improved obviously.