Abstract: Aiming at the complex electromagnetic interference, this paper adopts the principle of transmission zero point produced by electromagnetic coupling cancellation, and proposes a wide-band rejection filter based on electromagnetic coupling cancellation. The odd-even mode analysis is performed on the circuit resonant unit, the circuit is designed by the ADS software, and then the circuit is optimized by three-dimensional simulation with the HFSS software, and finally it is manufacuured by LTCC material. The device adopts left and right symmetrical structure to reduce design complexity and component volume; determines the zero position by electromagnetic coupling cancellation principle; adjusts the resonance spacing to achieve zero point control; adds source load coupling to achieve the fourth transmission zero point, enhances selectivity and the stop band width. The final wide stop-band filter is designed with a physical size of 3. 2 mm ×1. 6 mm ×0. 89 mm. The physical test results show that the device has a wide stop band and a high steepness in the pass band.