Abstract: Microwave may be used in the disinfection for solid media of edible fungi.The conditions and mechanism of it are studied.The results show,microwave has efficiently function of disinfection on the solid media of edible fungi and complete disinfectional effect can be achieved.The disinfectional results of microwave is related with the disinfectional time and the temperature of the solid media.There are thermal effect and non-thermal effect during the disinfection for solid media through with microwave.